Polynucleotides (PN) and polydeoxyribonucleotides (PDRN) — the science behind the treatment often called the “salmon-DNA facial” — are transforming aesthetic medicine. Rejuran® harnesses purified, hydrolyzed DNA fragments to help your skin repair and renew itself from within, rather than simply filling or freezing it.
The power of premium salmon DNA
First developed for wound healing, salmon-derived DNA carries regenerative properties unmatched in nature. Rejuran’s patented DNA Optimization Technology (DOT™) uses the finest-grade wild salmon, extracted and purified to the highest clinical efficacy — the gold standard in regenerative aesthetics.
Clinically shown to support
Natural skin renewal from deep within
Healthy collagen production
Improved skin density & elasticity
Reduced visible redness & sensitivity
Radiant, healthy-looking skin
Global leadership through innovation
#1 skin booster in South Korea
Injectable formulation approved in 14 countries
FDA approval pending in the United States
30+ years of proven safety & efficacy
PDRN / PN Compatibility
Human
Adenine30%
Thymidine30.3%
Guanine19.5%
Cytosine19.9%
vs
Salmon
Adenine27%
Thymidine29.1%
Guanine20.8%
Cytosine20.4%
97%
Compatible with human DNA
The Cosmetiq Difference
Regeneration you can see — science you can trust.
Cosmetiq Medicine • Portland, OR & Vancouver, WA • Regenerative Aesthetics
The evidence behind the glow
Clinical Studies
Rejuran’s DOT™ technology has been studied in peer-reviewed, randomized clinical trials. Here is what the research shows about how salmon-DNA polynucleotides help your skin rebuild itself.
Stimulates Your Own Collagen
DOT™ promotes cell growth through fibroblast proliferation — the engine of new collagen — for firmer, healthier skin over time.
Rejuran® DOT™HA fillerControl
Deeper Hydration & Firmer Skin
In clinical testing, DOT™ increased skin hydration by 14.69% and skin elasticity by 21.78% — visibly plumper, springier skin.
Mean % increase after treatment
Rebuilds Skin From Within
DOT™ increases dermal thickness, forming a stronger defense barrier against the environmental factors that drive premature aging.
Thicker, More Resilient Skin
Epidermal thickness also rose significantly versus saline and hyaluronic-acid controls — skin that looks and feels more substantial.
Ref: Chang-sik Pak et al. “A phase-3, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study comparing the durability, efficacy and safety of polynucleotide filler and hyaluronic-acid filler in the correction of crow’s feet.” J Korean Med Sci 2014;29:201–209. • Seoul National University Bundang Hospital report. • “Long-chain polynucleotide gel and skin biovitalization.” J Plast Dermatol 2007;3(3).
Regenerative aesthetics · Portland & Vancouver
Rediscover skin that heals itself.
Ask our team whether Rejuran® is right for your skin goals — and design a personalized regenerative treatment plan.
Rejuran® is a registered trademark of PharmaResearch. Rejuran is not currently FDA-approved in the United States; availability and treatment suitability are determined during a professional consultation. Clinical data reflect published study results; individual results vary. This material is for patient education and is not medical advice.
COSMETIQ MEDICINE | Portland, OR & Vancouver, WA | Regenerative & Aesthetic Medicine
